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KMID : 0061119820100000001
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Bulletin of the Clinical Research Institute
1982 Volume.10 No. 0 p.1 ~ p.1
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Primary Hepatocellular Carcinoma and Hepatitis B Virus Infection in Korea
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Chung, Whan-Kook
Sun, Hee-Sik/Park, Doo-Ho
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Abstract
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Serological evidence of hepatitis B virus (HBV) infection and serum alphafetoprotein (AFP) were assayed in sera from 112 Korean patients with primary hepatocellular carcinoma (PHC) and from 63 age; and sex-matched controls. Serological evidence of HBV infectionwas found in 100% of PHC patients and in 97010 of controls. The majority of PHC patients (87%) were positive for hepatitis B surface antigen (HBsAg). In contrast, only 14% of control individuals were positive for HBsAg, but 82% were positive for antibody to HBsAg (anti HBs). Hepatitis B e antigen (HBeAg) was detected in a high percentage (38%) of HBsAg-positive PHC patients, but in none of the nine HBsAg-positive control individuals. Serum AFP was detectable in 83% of PHC patients but in only one of 63 controls (1.5%). These results document that HBV infection may be the major factor in the development of PHC in this country.
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KEYWORD
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